Microsoft 365 Mobility and Security exam Dumps

MS-101 exam Format | Course Contents | Course Outline | exam Syllabus | exam Objectives

Implement modern device services (30-35%)
Implement Mobile Device Management (MDM)
• plan for MDM
• configure MDM integration with Azure AD
• set an MDM authority
• set device enrollment limit for users

Manage device compliance
• plan for device Compliance
• design Conditional Access Policies
• create Conditional Access Policies
• configure device compliance policy
• manage Conditional Access Policies

Plan for devices and apps
• create and configure Microsoft Store for Business
• plan app deployment
• plan device co-management
• plan device monitoring
• plan for device profiles
• plan for Mobile Application Management
• plan mobile device security

Plan Windows 10 deployment
• plan for Windows as a Service (WaaS)
• plan the appropriate Windows 10 Enterprise deployment method
• analyze upgrade readiness for Windows 10
• evaluate and deploy additional Windows 10 Enterprise security features

Implement Microsoft 365 security and threat management (30-35%)
Implement Cloud App Security (CAS)
• configure Cloud App Security (CAS)
• configure Cloud App Security (CAS) policies
• configure Connected apps
• design Cloud App Security (CAS) Solution
• manage Cloud App Security (CAS) alerts
• upload cloud app security (CAS) traffic logs

Implement threat management
• plan a threat management solution
• design Azure Advanced Threat Protection (ATP) implementation
• design Microsoft 365 ATP Policies
• configure Azure ATP
• configure Microsoft 365 ATP Policies
• monitor Advanced Threat Analytics (ATA) incidents

Implement Windows Defender Advanced Threat Protection (ATP)
• plan Windows Defender ATP Solution
• configure preferences
• implement Windows Defender ATP Policies
• enable and configure security features of Windows 10 Enterprise

Manage security reports and alerts
• manage service assurance dashboard
• manage tracing and reporting on Azure AD Identity Protection
• configure and manage Microsoft 365 security alerts
• configure and manage Azure Identity Protection dashboard and alerts

Manage Microsoft 365 governance and compliance (35-40%)
Configure Data Loss Prevention (DLP)
• configure DLP Policies
• design data retention policies in Microsoft 365
• manage DLP exceptions
• monitor DLP policy matches
• manage DLP policy matches

Implement Azure Information Protection (AIP)
• plan AIP solution
• plan for deployment On-Prem rights management Connector
• plan for Windows information Protection (WIP) implementation
• plan for classification labeling
• configure Information Rights Management (IRM) for Workloads
• configure Super User
• deploy AIP Clients
• implement Azure Information Protection policies
• implement AIP tenant key

Manage data governance
• configure information retention
• plan for Microsoft 365 backup
• plan for restoring deleted content
• plan information Retention Policies

Manage auditing
• configure audit log retention
• configure audit policy
• monitor Unified Audit Logs

Manage eDiscovery
• search content by using Security and Compliance Center
• plan for in-place and legal hold
• configure eDiscovery and create cases

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MS-101 Mobility Test Prep

MS-101 Mobility Test Prep

MS-101 Mobility Test Prep :: Article Creator

stronger Mobility With Metformin in sufferers With Myotonic Dystrophy type 1

summary and introductionsummary

Metformin, the typical anti-diabetic drug, has been shown lately to Strengthen the grip verify efficiency of the DMSXL mouse mannequin of myotonic dystrophy class 1. The drug can also have positively affected muscle characteristic via a couple of molecular mechanisms, on RNA splicing, autophagia, insulin sensitivity or glycogen synthesis. Myotonic dystrophy continues to be very nearly an unmet clinical need. because metformin advantages from a fine toxicity profile, we investigated its capabilities for improving mobility in patients. Forty ambulatory grownup patients were recruited consecutively at the neuromuscular reference centre of Henri-Mondor medical institution. members and investigators were all blinded to remedy until the conclusion of the trial. Oral metformin or placebo turned into offered thrice each day, with a dose-escalation duration over 4 weeks up to 3 g/day, adopted by 48 weeks at optimum dose. The primary outcomes become the trade in the distance walked right through the 6-minute stroll check, from baseline to the end of the analyze. Concomitant adjustments in muscle energy and impact on myotonia, gait variables, organic parameters and exceptional of lifestyles have been explored. sufferers randomized into two arms eventually revealed identical results in all genuine measures and in the suggest 6-minute walk check at baseline. For the 23/40 patients who utterly achieved the 1-year study, adjustments between the corporations were statistically colossal, with the handled group (n = 9) gaining a distance of 32.9 ยฑ 32.7 m, whereas the placebo neighborhood (n = 14) received three.7 ยฑ 32.four m (P < 0.05). This development in mobility become linked to a rise in total mechanical energy (P = 0.01), due to a concomitant increase in the cranial and antero-posterior instructions suggesting an effect of the treatment on gait. Subanalysis published tremendous effects of metformin medication on the 6-minute walk check on the first intermediate assessment (after sixteen weeks of treatment), quantitatively similar to these recorded at 1 12 months. In distinction, except for the expected constrained weight loss linked to metformin medication, there became no trade in any of the other secondary endpoints, including myotonia and muscle power. sufferers in the treated group had a better incidence of light-to-reasonable adverse effects, normally gastrointestinal dysfunctions that required symptomatic medication. despite the fact results have been statistically massive best for the per protocol inhabitants of patients and not in the intent-to-treat analysis, metformin at the maximal tolerated dose supplied a promising effect on the mobility and gait knowledge of myotonic patients. These encouraging outcomes acquired in a small-scale monocentric section II study demand replication in a smartly-powered multicentre section III trial.

Introduction

Myotonic dystrophy classification 1 (DM1; OMIM #160900), an autosomal dominant monogenic disorder brought about via an unstable CTG enlargement, is the most commonplace sort of muscular dystrophy in adults. DM1 phenotype is characterized by a multi-systemic array of signs, amongst which is altered mobility secondary to primary muscle weak spot, wasting and myotonia, which represents the leading disorder burden (De Antonio et al., 2016). Beside contemporary advances in symptomatic cures for sleepiness (Puymirat et al., 2012) or myotonia (Logigian et al., 2010), DM1 has remained practically an unmet clinical want.

Over latest years, we now have assessed pathological mechanisms associated with DM1 using cells differentiated from human pluripotent stem cellphone strains derived from DM1 mutated gene-carrying embryos and from affected grownup DM1 sufferers (Marteyn et al., 2011; Gauthier et al., 2013). during this research programme, we now have recognized that the compound metforminโ€”the most widespread anti-diabetic drugโ€”can set off adjustments towards normalization in ratios of protein isoforms, the alteration of which is associated to quite a few DM1 medical symptoms (Laustriat et al., 2015). subsequently, we showed that equivalent metformin-brought on organic consequences on alternate RNA splicing changes came about in vivo in diabetic sufferers exposed to the drug. These results are, therefore, now not particular to DM1. while non-DM1 particular, metformin counteracts alternative splicing deregulation of a subset of genes established to be affected in DM1, comparable to different compounds mentioned via others [e.g. manumycin (Oana et al., 2013), chromomycin (Ketley et al., 2014), pentamidine (Warf et al., 2009), furamidine (Siboni et al., 2015), resveratrol (Takarada et al., 2015)]. These a good suggestion results were observed at extraordinarily high concentrations of the drug. A complementary study using the DMSXL mouse model of the disorder published a statistically gigantic practical benefit on motor trying out after metformin treatment. although, the hyperlink with a organic impact on alternate splicing of certain genes become not centered and metformin may also have caused that behavioural improvement by means of other molecular mechanisms, e.g. autophagia (Brockhoff et al., 2017), glycogen synthesis (Scalzo et al., 2017) or insulin sensitivity (for assessment see Dial et al., 2018; Kjobsted et al., 2018).

Altogether, despite this uncertainty on the mode of motion, these superb experimental consequences and the very first rate safeguard profile of metformin led us to undertake the latest scientific trial designed to explore the consequences of the drug on mobility in non-diabetic grownup DM1 sufferers. The 6-minute walk verify (6MWT), a strong functional verify to investigate mobility, changed into selected as the simple endpoint of practical means effect measures, in agreement with the options of the influence Measures in Myotonic Dystrophy class 1 (OMMYD-2) knowledgeable consensus (Gagnon et al., 2015). A collection of secondary outcomes explored concomitant adjustments in muscle energy, myotonia, gait variables, biological parameters and pleasant of lifestyles.


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